Ventricular changes in neurocognitive disorders Lead Investigator: Ana Manera Institution : Montreal Neurological Institute-McGill E-Mail : ana.manera@mcgill.ca Proposal ID : 1340 Proposal Description: Goals: -Compare volumetric ventricular changes between different neurocognitive disorders -Ventricular shape analysis in AD, bvFTD, PPA, LBD, Vascular and other dementia syndromes Objectives: Previous work from the group on a bvFTD cohort found that ventricle enlargement was the most sensitive differenciator from controls and predictor of disease progression. From visual inspection the shape of ventricles in bvFTD is different as that seen in AD or other dementias. In addition, the rate of enlargement is different across different dementia cohorts. Our main aim for this project is to prove that ventricles could serve as a reliable biomarker of bvFTD that would allow the differential diagnosis of bvFTD from other dementias. Our main objective is to precisely define and compare the pattern of ventricular enlargement amongst subjects with dementia of different etiologies (i.e. Alzheimer's disease, behavioral variant frontotemporal dementia, semantic dementia, progressive non-fluent aphasia, vascular dementia, Lewy Body disease)using volumetric and shape analysis on segmented ventricles from T1-weighted scans. T1-weighted scans for each subject will be pre-processed through our local pipeline(Aubert-Broche et al. 2013). I will work in collaboration with other postdoctoral researcher with expertise in brain imaging processing, under the cosupervision of Dr. Louis Colins and Dr. Simon Ducharme. We have recently worked together in a project focused on identifying morphometric baseline and longitudinal difference between bvFTD and controls (Under review, Neuroimage: Clinical Journal) and individual prediction of bvFTD subjects using Random Forest algorithm with accuracies ov